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Sumatriptan is a selective agonist of vascular 5-hydroxytryptamine-1-receptors (5-HT1D), does not affect other subtypes of 5-HT receptors (5-HT2-5-HT7). 5-HT1D receptors are located mainly in the cranial blood vessels of the brain, and their stimulation leads to narrowing of these vessels. In animals, sumatriptan selectively acts on vasoconstriction of branches of the carotid artery, without affecting blood flow in the vessels of the brain. The vascular pool of the carotid artery supplies blood to extracranial and intracranial tissues (including meningeal membranes), and it is believed that the expansion of these vessels and / or swelling of their walls is the main mechanism of migraine in humans. In addition, preclinical data suggest that sumatriptan reduces the sensitivity of the trigeminal nerve. Both of these effects may underlie the antimigrenous action of sumatriptan. Imitrex without prescription is effective in the treatment of menstrual migraine, i.e. migraines without aura, which occurs 3 days before and 5 days after the menstrual cycle. The clinical effect is usually noted 30 minutes after oral administration of 100 mg of the drug. Despite the fact that the recommended dose for oral administration is 50 mg, migraine attacks vary in severity both in one patient and in different patients. Doses from 25 mg to 100 mg have shown greater efficacy compared to placebo in clinical studies, but a dose of 25 mg is statistically significantly less effective than 50 mg and 100 mg. hfgrt4756672

The tablet should be swallowed whole, washed down with water. For adults Sumatriptan no rx is used for intermittent therapy of migraine attacks. The drug should not be used for preventive purposes. Treatment with sumatriptan should be started as early as possible after the onset of a migraine attack, but the drug is equally effective at any stage of the attack. The recommended dose of Sumatriptan no prescription is 50 mg, in some cases the dose may be increased to 100 mg. If the patient feels better after the first dose, and then the symptoms resume, you can take a second dose within the next 24 hours, provided that a minimum time interval of two hours is observed between the two doses. If the patient's first dose of sumatriptan did not have an effect, the second dose of the drug should not be used to stop the same migraine attack. In this case, paracetamol, acetylsalicylic acid or nonsteroidal anti-inflammatory drugs may be prescribed. Sumatriptan can be taken to relieve subsequent seizures. Sumatriptan is recommended to be used as a migraine monotherapy, sumatriptan should not be used simultaneously with ergotamine or its derivatives (including metisergide). Patients with impaired liver function: the recommended dose is 50 mg.

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